Cardiovascular Diseases & Diagnosis

Claudio Léo Gelape

Publications

• Research Article
  Effect of On-Pump CABG (Roller Versus Centrifugal Systems) on MCP-1, TNFsR and IL6 Behaviour
  Author(s): Renato Braulio, Marcelo Dias Sanches, Antonio Lúcio Teixeira Junior, Mauro Martins Teixeira, Paulo Henrique Nogueira Costa, Antonio Luiz Pinho Ribeiro, Claudia Alves Couto and Claudio Léo GelapeRenato Braulio, Marcelo Dias Sanches, Antonio Lúcio Teixeira Junior, Mauro Martins Teixeira, Paulo Henrique Nogueira Costa, Antonio Luiz Pinho Ribeiro, Claudia Alves Couto and Claudio Léo Gelape
  
  Background We aimed to evaluate the cytokines monocyte chemotactic protein 1 (MCP-1), TNF soluble receptor (TNF-sR1) and interleukin 6 (IL-6) behavior in patients submitted to CABG (coronary artery bypass grafting) surgeries comparing roller to centrifugal extracorporeal circulation (ECC) pumping systems. Methods We randomized prospectively 43 adults who had elective on-pump CABG with the use of a roller (group I; n = 22) or a centrifugal system (group II; n = 21). Plasma levels of MCP-1, TNF-sR1 and IL-6 were determined by Elisa before the induction of anaesthesia (T1), 35 min after initiation of ECC (T2), 1 min after aortic declamping (T3), and 2, 6 and 24 h after the operation (T4, T5 and T6, respectively). The two groups were matched according to preoperative features. The groups I and II showed similar perioperative characteristics and clinical postoperative outcomes. The plasma .. Read More»
  DOI: 10.4172/2329-9517.1000186

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