Journal of AIDS & Clinical Research

Collen Masimirembwa

Publications

• Research Article
  Evaluation of the Prevalence, Progression and Severity of Common Adverse Reactions (Lipodystrophy, CNS, Peripheral Neuropathy, and Hypersensitivity Reactions) Associated with Anti-Retroviral Therapy (ART) and Anti-Tuberculosis Treatment in Outpatients in Zimbabwe
  Author(s): Tafireyi Nemaura, Milcah Dhoro, Charles Nhachi, Gerard Kadzirange, Prosper Chonzi and Collen MasimirembwaTafireyi Nemaura, Milcah Dhoro, Charles Nhachi, Gerard Kadzirange, Prosper Chonzi and Collen Masimirembwa
  
  Introduction: The use of many anti-retroviral drugs has been associated with a myriad of adverse drug reactions (ADRs) which could limit successful treatment outcome with respect to patient compliance and quality of life. An additional consideration is the high incidence of HIV infection with tuberculosis (TB) in Southern Africa, including Zimbabwe, and the use of co-treatment regimens. Methods: The study is a cross sectional, case-control study of 433 out-patients conducted at two hospitals in Zimbabwe. The patients were profiled for adverse reactions namely central nervous system side-effects (CNS), lipodystrophy (LD), skin hypersensitivity (SH), and peripheral neuropathy (PN). Assignment of the case and the control status of a patient was done based on occurrence of these adverse drug reactions in each of the HIV/AIDS only, TB only and HIV/TB co-infection patient groups... Read More»
  DOI: 10.4172/2155-6113.1000203

  Abstract PDF