Pulmonary & Respiratory Medicine

Coralie Afeldorfer

Publications

• Research Article
  Mice Lacking Epithelial I-?B Kinase are Protected from Lipopolysaccharide and Cigarette Smoke Extract Induced Inflammation
  Author(s): David Lamb, Nicole Parker, Kristina Ulrich, Gareth Jones, Coralie Afeldorfer, Manolis Pasparakis, Steven Evans and Iain KiltyDavid Lamb, Nicole Parker, Kristina Ulrich, Gareth Jones, Coralie Afeldorfer, Manolis Pasparakis, Steven Evans and Iain Kilty
  
  Background: IKK-2 activity is essential for cytokine mediated NFκB activation and subsequent expression of a wide variety of inflammatory genes. To investigate the role of IKK-2 signalling in lung epithelium we have developed a knock out mouse in which we have specifically deleted the IKK-2 gene in lung epithelial cells. Materials and Methods: IKK-2 KO mice and littermate control animals were challenged with either nebulised Lipopolysaccharide (LPS) or with Cigarette Smoke Extract (CSE). Cytokines and inflammatory cells were assessed in Bronchoalveolar Lavage Fluid (BALF) and tissue inflammatory cells, markers of apoptosis and general pathology assessed histologically. Results: BALF neutrophils were reduced by 63% at 4 hours and 67% at 8 hours following LPS c.. Read More»
  DOI: 10.4172/2161-105X.1000142

  Abstract PDF