Journal of Clinical Case Reports

Cristina Iosif

Publications

• Case Report
  Rectal and Liver Metachronous Cancers and Sorafenib-Induced Thyroid Dysfunction.
  Author(s): Ancuta Augustina Gheorghisan Galateanu, Mara Carsote, Dan Peretianu, Cristina Iosif, Dana Terzea and Catalina PoianaAncuta Augustina Gheorghisan Galateanu, Mara Carsote, Dan Peretianu, Cristina Iosif, Dana Terzea and Catalina Poiana
  
  Background: The tyrosine kinase inhibitor, a new treatment option in hepatic carcinoma, may associate thyroid dysfunction like spontaneously remitting thyrotoxicosis followed by hypothyroidism. Case report: A 66-year Caucasian female was first diagnosed and operated for a moderately differentiated rectal adenocarcinoma of 5 centimeters. Immunohistochemistry showed positive VEGF receptor 2 (Flk-1, KDR), VEGF receptor 1(Flt-1), and a Ki67 of 30%. 4 years later a hepatic adenocarcinoma (clear cells variant) was diagnosed. After surgery, daily 400 mg of sorafenib was introduced. Three months later mild symptomatic thyrotoxicosis was seen: palpitations, fatigue, and mild bilateral pedal clonus. Thyroid-stimulating hormone (TSH) was suppressed (0.044 μIU/mL, normal levels between 0.4 and 4.5 μIU/mL), and free levothyroxine (fT4) eleva.. Read More»
  DOI: 10.4172/2165-7920.1000530

  Abstract PDF