Journal of AIDS & Clinical Research

Curtis Cooper

Publications

• Research Article
  Viral Suppression and Discontinuation Rates have Improved in HIV Patients with Modern Antiretroviral Therapies
  Author(s): Patrick Hamel, Ashley M Yu, Sarwat Khan, Daniel J Corsi and Curtis CooperPatrick Hamel, Ashley M Yu, Sarwat Khan, Daniel J Corsi and Curtis Cooper
  
  Objective: Rates and determinants of first-line antiretroviral (ARV) discontinuation or change in prescribed regimen were assessed between old (pre-2006) and modern (post-2006) era stratified by dosing frequency [(once daily (QD) versus twice or more daily (BID+)]. Methods: A single-center retrospective cohort study was conducted. All adult HIV patients initiating ARVs from January 1995-November 2015 were included. Patients were stratified by old- or modern-era and by dosing frequency. The primary outcome was rate of ARV therapy discontinuation or change in initial regimen. The secondary outcome was reason for discontinuation. Results: 1,127 patients were included from the old (n=621) and modern era (n=506). Modern-era patients were more likely to receive QD regimens (p<0.001) and had increased viral suppression at the last recorded testing than oldera patients (70.9% vs. 43.2%, .. Read More»
  DOI: 10.4172/2155-6113.1000660

  Abstract PDF