Journal of AIDS & Clinical Research

Cyrille Delpierre

Publications

• Research Article
  Incidence and Risk Factors of First-Line HAART Discontinuation: Is it Worth Choosing Competing Risk or Standard Survival Approaches?
  Author(s): Momory Keita, Cecile Chouquet, Lise Cuzin, Mohamed Cisse, Thierry Lang and Cyrille DelpierreMomory Keita, Cecile Chouquet, Lise Cuzin, Mohamed Cisse, Thierry Lang and Cyrille Delpierre
  
  Objectives: To estimate the incidences of first-line HAART discontinuation (for intolerance, treatment failure or treatment simplification) and their risk factors by standard survival (1-KM, Cox model) or competing risk approach (CIF, Fine-Gray model) in HIV infected patients. Methods: We studied 1136 patients receiving first-line Highly Active Antiretroviral Therapies (HAART), aged over 18 years, from the Dat’AIDS cohort, Toulouse, France, between January 2000 and June 2008. Cumulative incidence was estimated with 1-KM and CIF estimators and risk factors with Cox and Fine-Gray models. Results: There were 265 discontinuations for intolerance, 136 simplifications, 101 treatment failure and 274 other reasons. One year incidences were 19.0% versus 16.8%, 8.0% versus 6.0%, 6.3% versus 4.8% and 20.0% versus 17.3%, with the estimators 1-KM and CIF, respectively. For intolerance, both .. Read More»
  DOI: 10.4172/2155-6113.1000187

  Abstract PDF