Journal of Clinical Case Reports

D Intiso

Publications

• Case Report
  High Dose of Botulinum Toxin Type A (NT-201) for the Treatment of Dysphagia due to Severe Spasticity of Upper Oesophageal Sphincter: A Case Report
  Author(s): M Basciani and D IntisoM Basciani and D Intiso
  
  Background: Botulinum toxin type A (BoNT-A) has been used in treating dysphagia due to spasticity of upper oesophageal sphincter (UES). However, the doses commonly injected could result ineffective. A case of dysphagia treated successfully by high dosage of BoNT-A is described. Case report: A 50 year-old male subject with tetraparesis and dysphagia due to severe spasticity of UES following encephalitis. No bolus transit was observed to videofluoroscopy (VS). Because of severe UES spasticity, it was not possible to perform oesophageal manometry. Growing BoNT-A dosage of 10 U (Botox) and 100 U (Xeomin) injected into cricopharingeal muscle (CM) had no benefit. Since negative effect of previous doses, BoNT-A (Xeomin) high dosage of 200 U was injected into CM. After neurotoxin injections,VS showed significant dysphagia improvement lasting .. Read More»
  DOI: 10.4172/2165-7920.1000577

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