Journal of Oncology Translational Research

Dale Buchanan Hales

Publications

• Short Communication
  Detection and Characterization by Immunohistochemistry of the NGcGM3 Ganglioside in the Chicken Animal Model of Ovarian Cancer
  Author(s): Angel Casaco Parada, Addy Gonzalez Palomo, Dale Buchanan Hales, Karen Hales and Luis Enrique FernandezAngel Casaco Parada, Addy Gonzalez Palomo, Dale Buchanan Hales, Karen Hales and Luis Enrique Fernandez
  
  In spite of ovarian cancer mortality rates have tended to level off and decrease during the last years in several countries, the disease is still the gynecological cancer with the highest death rate. The current therapies for ovarian cancer include surgery and chemotherapy based on platinum and a taxane. Nevertheless, these therapies are only efficient at the first stages of the disease and the treatments are lack of specificity, further contributing to the high mortality rates of ovarian cancer. The adult laying hen is a very interesting model for studying the development of the epithelial ovarian cancer since hen develops intense ovulation, spontaneous ovarian cancers and metabolic progression similar to women. It is known that normal chicken cells and human cells have no metabolic pathway for NeuGc biosynthesis due to a partial deletion in the gene that.. Read More»
  DOI: 10.4172/2476-2261.1000123

  Abstract PDF