Journal of Hypertension: Open Access

Dale Seth

Publications

• Research Article
  Brain-Targeted (Pro) Renin Receptor Knockdown Modulates Body Fluid Homeostasis
  Author(s): Theresa Cao, Wencheng Li, Dale Seth, L Gabriel Navar and Yumei FengTheresa Cao, Wencheng Li, Dale Seth, L Gabriel Navar and Yumei Feng
  
  Objectives: The (pro) renin receptor (PRR) is highly expressed in the brain and is involved in the central regulation of blood pressure. However, the role of the brain PRR in regulating body fluid homeostasis in hypertension remains unclear. We hypothesized that the brain PRR knockdown modulates water intake, urine, and urinary sodium excretion in the context of angiotensin II (Ang II)-induced hypertension. Methods and Results: Brain PRR was knocked down in non-transgenic (NT) normotensive and human reninangiotensinogen double-transgenic (RA) mice by intracerebroventricular (ICV) injection of adeno-associated virus expressing short hairpin RNA targeting the PRR (AAV-PRR-shRNA). Water and food intake, and urinary excretion were recorded using metabolic cages. At baseline, RA mice exhibited higher water intake, food intake, urine excretion, ur.. Read More»
  DOI: 10.4172/2167-1095.1000160

  Abstract PDF