Journal of AIDS & Clinical Research

Dan Wang

Publications

• Research Article
  Microvascular Endothelial Dysfunction and Enhanced Thromboxane and Endothelial Contractility in Patients with HIV
  Author(s): Dan Wang, Joseph K Melancon, Jennifer Verbesey, Haihong Hu, Chenglong Liu, Shaki, Aslam and Mary YoungDan Wang, Joseph K Melancon, Jennifer Verbesey, Haihong Hu, Chenglong Liu, Shaki, Aslam and Mary Young
  
  Background: The prevalence of cardiovascular disease is increased with human immunodeficiency virus (HIV) infection, but the mechanism is unclear. We hypothesized that HIV increases microvascular reactive oxygen species, thereby impairing endothelial function and enhancing contractility. Method: Subcutaneous micro arterioles were isolated from gluteal skin biopsies in premenopausal, African American, HIV positive women receiving effective anti-retroviral therapy, but without cardiovascular risk factors except for increased body mass index (n=10) and healthy matched controls (n=10). The arterioles were mounted on myographs, preconstricted and relaxed with acetylcholine for: endothelium-dependent relaxation, endotheliumdependent relaxation factor (nitric oxide synthase-dependent relaxation), endothelium-dependent hyperpolarizing factor (potassium-channel dependent relaxation) an.. Read More»
  DOI: 10.4172/2155-6113.1000267

  Abstract PDF