Journal of Surgery

Daniel E Hilleman

Publications

• Review Article
  Intravenous Acetaminophen: Assessment of Medication Utilization Evaluation Data in Peri-operative Pain Management
  Author(s): Mark A Malesker, Anne L Bruckner, Brian Loggie and Daniel E HillemanMark A Malesker, Anne L Bruckner, Brian Loggie and Daniel E Hilleman
  
  Intravenous (IV) acetaminophen has become an accepted component of a multimodal analgesic strategy in perioperative patients. It is currently a branded drug (Ofirmev®) in the United States. The purchase price of the drug is greater than oral and rectal acetaminophen, intravenous ketorolac, and parenteral opioids. As a result, a large number of medication utilization evaluations (MUEs) have been conducted to evaluate the appropriateness of IV acetaminophen use. Many of these MUEs have failed to demonstrate the expected benefits observed with the use of IV acetaminophen in randomized, controlled trials. This review summarizes the major methodological flaws seen in many of these MUEs. The most common flaws of the available MUEs were inclusion of inadequate numbers of patients, failure to adequately define the timing and duration of IV acetaminophen use, and failure to adequately matc.. Read More»
  

  Abstract PDF