Journal of Integrative Oncology

Daniel Scherman

Publications

• Review Article
  Reduction of Hepatotoxicity Induced by Doxorubicin
  Author(s): Dorsaf Bengaied, Antonio Ribeiro, Mohamed Amri, Daniel Scherman and Philippe ArnaudDorsaf Bengaied, Antonio Ribeiro, Mohamed Amri, Daniel Scherman and Philippe Arnaud
  
  Doxorubicin (DOX) has been used in the treatment of variety of cancers but its administration is limited by a dosedependent toxicity. Its cytotoxic effects on malignant cells have shown an increase in the risk of cardiotoxicity, hepatoxicity, renal insufisance. Antioxydants have been explored for both their cancer preventive properties and chemodulatory of DOX toxicity. Resveratrol (RSV) is a polyphenolic constituent of several dietary mainly of grapes and wine origin recently its anticancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo. RSV is also known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, RSV possesses great medicinal value, its applications as a therapeutic drug is limited. Problems like low oral bioavailability and poor.. Read More»
  DOI: 10.4172/2329-6771.1000193

  Abstract PDF