Journal of Nephrology & Therapeutics

Daniel W Coyne

Publications

• Research Article
  Relationship of 1,25 dihydroxy Vitamin D Levels to Clinical Outcomes in Critically Ill Patients with Acute Kidney Injury
  Author(s): Anitha Vijayan, Tingting Li, Adriana Dusso, Sanjay Jain and Daniel W CoyneAnitha Vijayan, Tingting Li, Adriana Dusso, Sanjay Jain and Daniel W Coyne
  
  Background: Calcitriol [1,25(OH)2D] plays a central role in endocrine regulation of bone and mineral metabolism. Low 1,25(OH)2D levels in chronic kidney disease (CKD) are associated with increased cardiovascular morbidity and mortality. However, the role of 1,25(OH)2D in acute kidney injury (AKI) is unclear, with very limited data. This pilot study examined the relationship between 1,25(OH)2D levels in critically ill patients with AKI and clinical outcomes. Methods: Plasma 1,25(OH)2D, intact parathyroid hormone (iPTH), 25-OH Vitamin D (VitD), calcium and phosphorus were measured in 34 patients with AKI without pre-existing chronic kidney disease and 12 healthy controls. Results: The mean 1,25(OH)2D levels were significantly lower in patients with AKI compared to controls, (42 ± 5.6 pg/mL vs. 76.1 ± 5.3 pg/mL, P<0.0001). The mortality in patients with AKI was 30%. 1,25.. Read More»
  DOI: 10.4172/2161-0959.1000190

  Abstract PDF