Journal of Clinical Case Reports

Dariusz Korczyk

Publications

• Research Article
  Brain Natriuretic Peptide Clearance in Patients with Obesity and Insulin Resistance - a Mechanistic Study
  Author(s): Dariusz Korczyk, Kevin Ng, Yohan Chacko, Goce Dimeski and Paul GouldDariusz Korczyk, Kevin Ng, Yohan Chacko, Goce Dimeski and Paul Gould
  
  Introduction: Brain Natriuretic Peptide (BNP) is secreted from cardiac myocytes in response to the wall stress. BNP is eliminated via Natriuretic Peptide Receptor C (NPR-C) and degradation by extracellular proteases including neprilysin (NEP). Obesity and insulin resistance predispose to lower circulating natriuretic peptide levels. Raised NEP activity and an elevated NPR-C gene expression have been described in obese individuals with insulin resistance and lower circulating levels of natriuretic peptide. Methods: We assessed the relationship between markers of peptide production and pulmonary clearance with indices of insulin resistance and body weight. The cardiac, peripheral and pulmonary Extraction Ratio (ER) has been quantified to assess BNP synthesis and clearance. Twenty one individuals admitted for EP study were consented. Simultaneous sampling of serum BNP level was performed.. Read More»
  DOI: 10.4172/2165-7920.1000647

  Abstract PDF