Journal of AIDS & Clinical Research

Darrell HS Tan

Publications

• Research Article
  Exploring Strategies for Attenuating Changes in Bone Mineral Density in Men who have Sex with Men Using Tenofovir/Emtricitabine Pre-exposure Prophylaxis
  Author(s): Jean-Luc Kortenaar, Angela M Cheung, Shabbir Mewa, Esther Waugh, Laurence Rubin and Darrell HS TanJean-Luc Kortenaar, Angela M Cheung, Shabbir Mewa, Esther Waugh, Laurence Rubin and Darrell HS Tan
  
  Objective: Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV pre-exposure prophylaxis (PrEP) decreases bone mineral density (BMD). We explored the impact of vitamin D supplementation, dietary calcium intake, and bone loading exercise on BMD during the first 12 months of daily TDF/FTC PrEP. Methods: All participants from the PREPARATORY-5 pilot demonstration project of gay and bisexual men were eligible for inclusion if they had dual-energy X-ray absorptiometry scans at both baseline and 12 months (n=39). Selfreported vitamin D supplementation was collected prospectively, whereas data on diet and exercise was obtained retrospectively after the trial period, using validated questionnaires. We compared median percent changes in BMD and trabecular bone score (TBS) between those with and without vitamin D supplementatio.. Read More»
  

  Abstract PDF