Cardiovascular Diseases & Diagnosis

David Barilla

Publications

• Case Report
  Thrombosis due to Heparin-Induced Thrombocytopenia in Cardiac Surgery: is Fondaparinux an Effective Treatment?
  Author(s): David Barilla, Gian Luca Martinelli, Attilio Cotroneo, Angelo Romano and Pasquale IacopinoDavid Barilla, Gian Luca Martinelli, Attilio Cotroneo, Angelo Romano and Pasquale Iacopino
  
  Objective: To determine whether fondaparinux is effective in the treatment of thrombosis due to heparin-induced thrombocytopenia (HIT) in cardiac surgery we reported three cases successfully treated with fondaparinux and withdrawal of all heparins. Patients: All three patients were female and underwent heart valve replacement using cardiopulmonary bypass. Combined clinical criteria, "4T score" (Thrombocytopenia, Timing, Thrombosis, and absence of oTher explanations) and laboratory testing have been used for diagnosis. In all patients the point of heparin immunization occurred in the preoperative period, during the angiography when a standard dose of UFH (5,000 IU) was administered. Then, during cardiac surgery, patients received a high dose of UFH, and later LMWH was used. Thrombocytopenia occurring between postoperative days 5 and 10 was associated with severe ven.. Read More»
  DOI: 10.4172/2329-9517.1000240

  Abstract PDF