Journal of AIDS & Clinical Research

David Burger

Publications

• Research Article
  Plasma Tenofovir Concentrations and Proximal Tubular Dysfunction in HIV-Infected Adults Receiving Tenofovir in Thailand
  Author(s): Anchalee Avihingsanon, Jiratchaya Sophonphan, Narukjaporn Thammajaruk, Prachya Chaihong, David Burger, Tim R Cressey, Reshmie A Ramautarsing, Kearkiat Praditornsilpa, Yingyos Avihingsanon, Kiat Ruxrungtham and HIV-NAT 114 study teamAnchalee Avihingsanon, Jiratchaya Sophonphan, Narukjaporn Thammajaruk, Prachya Chaihong, David Burger, Tim R Cressey, Reshmie A Ramautarsing, Kearkiat Praditornsilpa, Yingyos Avihingsanon, Kiat Ruxrungtham and HIV-NAT 114 study team
  
  Background: HIV-infected Asians may be at risk for tenofovir toxicity due to their relatively low body weight (BW). We assessed the prevalence of proximal tubular dysfunction (PRTD) and risk associated with PRTD in HIV-infected adults receiving tenofovir in Thailand. Methods: A cross-sectional study in HIV-infected adults (≥ 18years) treated with tenofovir for >1 year. Twenty-fourhour urine samples were collected to assess PRTD. PRTD was defined as the presence of >2 of the following criteria: hyper-phosphaturia (total excretion of phosphate >1200 mg/day or renal tubular reabsorption of phosphate (TmP/ GFR) < 2.6 mg/dl), hyper-uricosuria (FE of uric acid >15%), or non-diabetic glucosuria. Mid-dose tenofovir plasma concentrations were determined and concentrations >160 ng/mL were used as a cut-off for assessing risk of PRTD. Res.. Read More»
  DOI: 10.4172/2155-6113.1000477

  Abstract PDF