Journal of Tissue Science and Engineering

David Carr

Publications

• Research Article
  Synergy between Rhbmp-2 and IKK-Inhibitor PS-1145 Delivered via a Porous Biodegradable Polymer Implant
  Author(s): David Carr, Nicole Y.C Yu, Jane Fitzpatrick, Lauren Peacock, Kathy Mikulec, Andrew J. Ruys, Justin C. Cooper-White, David G. Little and Aaron SchindelerDavid Carr, Nicole Y.C Yu, Jane Fitzpatrick, Lauren Peacock, Kathy Mikulec, Andrew J. Ruys, Justin C. Cooper-White, David G. Little and Aaron Schindeler
  
  Critical-sized bone defects, whether caused by congenital malformation, tumor resection, trauma, or implant loosening, remain a major challenge for orthopaedic management. In this study we describe a bone tissue engineering approach in mice for the co-delivery of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) and the IKK inhibitor PS-1145. Scaffold implants were manufactured from poly(lactide-co-glycolide)(PLGA) by Thermally-Induced Phase Separation (TIPS), with rhBMP-2 (10 μg) and the IKK inhibitor PS-1145 (0 μg, 40 μg or 80 μg) incorporated into the polymer. These scaffolds were then surgically implanted into the hind limb muscle of C57BL6/J mice. One group of mice also received systemic 50 mg/kg PS-1145 (days 11-20). Specimens were harvested at week 3 for X-ray and microCT analyses and descriptive histology. Local and systemic delivery PS-1.. Read More»
  DOI: 10.4172/2157-7552.S1-003

  Abstract PDF