Journal of AIDS & Clinical Research

David M Asmuth

Publications

• Research Article
  Differential Specificity of Interferon-alpha Inducible Gene Expression in Association with Human Immunodeficiency Virus and Hepatitis C Virus Levels and Declines in vivo
  Author(s): Antonios Katsounas, Astrid C Frank, Richard A Lempicki, Michael A Polis, David M Asmuth and Shyam KottililAntonios Katsounas, Astrid C Frank, Richard A Lempicki, Michael A Polis, David M Asmuth and Shyam Kottilil
  
  Objective: This study was aimed to correlate in vivo interferon (IFN) inducible gene (IFIG) expression and IFIG induction with viral-load (VL) and VL-kinetics of Human-Immunodeficiency-Virus (HIV) or Hepatitis-C-Virus (HCV) in HIV-positive patients treated with pegylated IFN-alpha-2a (PegIFNα). Methods: HIV mono-infected patients (N=8) and HIV/HCV co-infected patients (N=23, without HIV-viremia) were treated with PegIFNα (180 μg/week) for 12 and 48 weeks, respectively. Blood sampling for monitoring IFIG expression occurred at day_0 and week_3, _6 and _12 for HIV mono-infected patients vs. only at day_0 and week_48 for HIV/ HCV co-infected subjects. IFIG expression (N=20) was measured in peripheral blood mononuclear cells by bDNAassay. VL levels/changes in plasma were analyzed for correlation with IFIG expression/induction at/between selected t.. Read More»
  DOI: 10.4172/2155-6113.1000410

  Abstract PDF