Molecular Biology: Open Access

David Rekosh

Publications

• Research Article
  REV Responsive Element Polymorphism from Gp41 of Human Immunodeficience Virus Type 1 and Antiretroviral Susceptibility Impact in Patients from Northeast Brazil
  Author(s): Melissa Medeiros, Erico Arruda, Christopher Brown, Jamily Maciel, Marie-Louise Hammarskjold, David Rekosh and Aldo LimaMelissa Medeiros, Erico Arruda, Christopher Brown, Jamily Maciel, Marie-Louise Hammarskjold, David Rekosh and Aldo Lima
  
  Introduction: Rev Responsive Element (RRE) is a RNA molecule responsible to mRNA from HIV-1 virus nuclear transportation to cytoplasm through RRE-Rev pathway, essencial to virus replication. Enfuvirtide resistance mutations are primary located in a perimeter of 10 amino acids of HR1, a corresponded region of RRE. Charactherize RRE should provide a new approach for HIV therapy. Objectives: Sequence and characterize RRE from gp41 to evaluate variability and correlate with laboratory parameters in sequences from HIV-1-infected patients, whitch were receiving regimens including Enfuvirtide, naïve or rescue therapy. Methods: Sixty-two samples from HIV patients in Northeast Brazil were collected and Thirty-five RRE sequences and clinical follow-up were analyzed, distributed into three groups: N (naïve therapy), T (.. Read More»
  DOI: 10.4172/2168-9547.1000110

  Abstract PDF