Journal of Cytology & Histology

Debek W

Publications

• Research Article
  Mast Cells Connections with Nerve Fibers in Hirschsprung's Disease
  Author(s): Hermanowicz A, Matuszczak E, Komarowska M, Debek W, Chyczewski L and Klek SHermanowicz A, Matuszczak E, Komarowska M, Debek W, Chyczewski L and Klek S
  
  Introduction: Hirschsprung’s disease (HD) is rare (1/5000 newborns) congenital condition of the bowel nervous system, clinically characterized by dilatation and hypertrophy of colon. There are an increased number of mast cells (MC) in aganglionic bowel segments and in those with intestinal neuronal dysplasia (IND). The exact role of MC in HD is still not known. The aim of this study was to examine the colonic distribution of mast cells (MC) and the relationship between MC and nerve fibers and to estimate connections of these cells with gut nervous system. Material and Methods: Distal colon wall specimens were harvested from patients with normal bowel function and with normal ganglion cells, patients with constipations and with normal ganglion cells and a group of patients with Hirschsprung’s disease. The age of the patients ranged from 2nd day of live to 12 years. The den.. Read More»
  DOI: 10.4172/2157-7099.1000201

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