Journal of Hypertension: Open Access

Deepak Malhotra

Publications

• Research Article
  Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone
  Author(s): Christopher A Drummond, George Buddny, Steven T Haller, Jiang Liu, Yanling Yan, Zijian Xie, Deepak Malhotra, Joseph I Shapiro and Jiang TianChristopher A Drummond, George Buddny, Steven T Haller, Jiang Liu, Yanling Yan, Zijian Xie, Deepak Malhotra, Joseph I Shapiro and Jiang Tian
  
  Gender difference has been suggested as a risk factor for developing cardiovascular and renal diseases in humans and experimental animals. As a major sex hormone, progesterone was reported to compete with cardiotonic steroid binding to Na/K-ATPase. Our previous publication demonstrated that cardiotonic steroids (e.g., marinobufagenin) play an important role in the development of experimental uremic cardiomyopathy. We also observed that the putative mineralocorticoid antagonists, spironolactone and its major metabolite canrenone, antagonize binding of cardiotonic steroids to Na/K-ATPase in a competitive manner and also ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy. In the following studies, we noted that progesterone displayed competitive inhibition of cardiotonic steroid binding to Na/K-ATPase and partially inhibited collagen synthesis induced by marinob.. Read More»
  DOI: 10.4172/2167-1095.1000109

  Abstract PDF