Journal of Lung Diseases & Treatment

Delsing L

Publications

• Research Article
  Finding the Patients for Respiratory Clinical Trials; Successful Recruitment by Adapting Trial Design
  Author(s): Delsing L, Jauhiainen A, Brailsford W, Buxtfeldt C, Sethi T and Betts JDelsing L, Jauhiainen A, Brailsford W, Buxtfeldt C, Sethi T and Betts J
  
  There is increasing need to develop new therapeutics for respiratory diseases such as asthma and COPD, driven by the rising global prevalence, association with significant morbidity and mortality and limited current treatment options. However, recruitment of patients into respiratory trials remains challenging, time-consuming and often very costly. As a consequence, recruitment times frequently have to be extended during the trial to reach the recruitment goal. To identify key changes in trial design which could lead to improved recruitment in respiratory trials, trial recruitment between 1999 and 2012 was analyzed using data from Citeline Trialtrove. The manner by which trials met their recruitment goal was analyzed together with a more in-depth study of trials terminated due to poor recruitment. The percentage of respiratory trials found not to be recruiting to target was substantia.. Read More»
  DOI: 10.4172/2472-1018.1000110

  Abstract PDF