Journal of General Practice

Denis S Loiselle

Publications

• Review Article
  Assessing the Efficiency of the Diabetic Heart at Subcellular, Tissue and Organ Level
  Author(s): Denis S Loiselle, June-Chiew Han, Kimberley M Mellor, Toan Pham, Kenneth Tran, Soyeon (Eden) Goo, Andrew J Taberner and Anthony JR HickeyDenis S Loiselle, June-Chiew Han, Kimberley M Mellor, Toan Pham, Kenneth Tran, Soyeon (Eden) Goo, Andrew J Taberner and Anthony JR Hickey
  
  In this review, we focus on the diabetic heart rather than the vascular complications of diabetes. Focus is further narrowed to a specific, but widely used, animal model: the diabetic rat heart in which diabetes has been induced by a single injection of streptozotocin. Our experimental approach is primarily biophysical and ranges from measurements made in isolated working whole-hearts, to those made from isolated left-ventricular tissues and mitochondria. Our interest is on the effect of severe diabetes on cardiac energetics, in terms of efficiency of cardiac work performance, ATP synthesis and oxygen consumption. By designing experiments to test the energetic performance of the heart and its trabeculae across a wide range of protocols, we have revealed the dependence of efficiency on afterload. This has allowed us to clarify a long-standing uncertainty in the literature; whereas the .. Read More»
  DOI: 10.4172/2329-9126.1000168

  Abstract PDF