Journal of Tissue Science and Engineering

Denise Cantarelli Machado

Publications

• Research Article
  The Role of DNA Damage and Repair Proteins in Adipose-Derived Adult Stem Cell Differentiation in Neural- Like Cells
  Author(s): Ana Paula Franco Lambert, Dinara Moura, Aline Fraga Zandonai, Mariana Assis Lemos, Jeremiah Lubianca, Christian Viezzer, Joao Alvaro Souza da Silva, Diego Diego Bonatto, Denise Cantarelli Machado and Joao Antonio Pegas HenriquesAna Paula Franco Lambert, Dinara Moura, Aline Fraga Zandonai, Mariana Assis Lemos, Jeremiah Lubianca, Christian Viezzer, Joao Alvaro Souza da Silva, Diego Diego Bonatto, Denise Cantarelli Machado and Joao Antonio Pegas Henriques
  
  The development of a clinically translatable method of engineering with adipose-derived adult stem (ADAS) for reconstruction requires investigation of several components. The differentiation of ADAS cells into neuronal cells has been reported by several groups. The stringent maintenance of genomic stability in adult stem cells via anti-stress defenses and DNA repair mechanisms is particularly important because any genetic alteration can compromise the genomic stability and functionality of the cell. The main objective of this data was to examine some parameters related to DNA damage in cells submitted to the neural differentiation protocol and to understand if DNA damage can be associated to cell differentiation. The comet assay, micronucleus tests, and the cell viability assay were utilized to observe ADAS cells treated with neural induction medium. .. Read More»
  DOI: 10.4172/2157-7552.1000109

  Abstract PDF