Cancer Science & Therapy

Derek A Pullum

Publications

• Research Article
  Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents
  Author(s): Jason B Garrison, Chunmin Ge, Lixiao Che, Derek A Pullum, Guang Peng, Sohaib Khan, Nira Ben-Jonathan, Jiang Wang and Chunying DuJason B Garrison, Chunmin Ge, Lixiao Che, Derek A Pullum, Guang Peng, Sohaib Khan, Nira Ben-Jonathan, Jiang Wang and Chunying Du
  
  Background and objectives: Management of patients with breast cancer often fails because of inherent or acquired resistance to chemotherapy. BRUCE (BIR repeat containing ubiquitin-conjugating enzyme) is a member of the inhibitor of apoptosis protein (IAP) family. It has various cellular functions including suppression of apoptosis and promotion of cytokinesis. Furthermore, it pays a critical role in promotion of DNA damage repair and preservation of genome stability, a new function recently reported by our group. Although BRUCE is expressed in breast cancer cell lines, its expression in human primary breast tumors and its contribution to chemoresistance in breast cancers has not been explored. Chemotherapeutic drugs are used in the treatment of breast cancer patients. However, they are not effective to all patients and patients often devel.. Read More»
  DOI: 10.4172/1948-5956.1000335

  Abstract PDF