Pulmonary & Respiratory Medicine

Determann RM

Publications

• Research Article
  Clara Cell Protein and Surfactant Protein D Plasma Levels are Associated with Clinical Outcomes of Mechanically Ventilated Patients
  Author(s): Determann RM, Royakkers AANM, Lutter R, Korevaar JC and Schultz MJDetermann RM, Royakkers AANM, Lutter R, Korevaar JC and Schultz MJ
  
  Background: Plasma levels of Clara cell protein (CC16) and Surfactant Protein D (SP–D) are elevated in patients with Acute Lung Injury or Acute Respiratory Distress Syndrome (ALI/ARDS). We investigated the relation between these biomarkers and clinical outcome scores from mechanically ventilated patients at risk for lung injury. Methods: Data from all 150 patients enrolled in a previously reported preventive randomized controlled trial, comparing a 10 ml/kg with a 6 ml/kg tidal volume strategy in patients without ALI/ARDS at the onset of mechanical ventilation, were used. CC16 and SP–D levels were measured in plasma samples at baseline and on day 2 and 4 after initiation of the mechanical ventilation protocol. The relation between CC16 and SP–D levels and development of ALI/ARDS (North American European Con.. Read More»
  DOI: 10.4172/2161-105X.1000138

  Abstract PDF