Journal of Material Sciences & Engineering

Dhivya R

Publications

• Research Article
  pH Triggered Curcumin Release from PMMA-AA Coated ZnO Nanoparticles for Excellent Anti-Gastric Cancer Therapy
  Author(s): Dhivya R, Ranjani J, Rajendhran J, Mayandi J and Annaraj JDhivya R, Ranjani J, Rajendhran J, Mayandi J and Annaraj J
  
  The curcumin loaded PMMA-AA/ZnO nanocomposite potentially inhibited the growth of AGS cancer tumour in male Swiss albino mouse, which showed a promising targeted cancer therapy. Interestingly the given bio-nanocomposite was rapidly cleared from the organs with negligible exhibition of toxicity. From the obtained results it is understood that the apoptosis has been occurred through mitochondrial disruption-mediated pathway. Also these nanomaterials could efficiently hinder the Go/G1 transition along with cycle progression at S-phase transition due to the radiation-induced DNA damage. These findings declared that the auspicious candidate, curcumin could be successfully delivered into the target by the polymer encapsulated ZnO NPs and exhibited a potent activity against gastric cancer cells at molecular and cellular levels as well as cell proliferation in a panel of tumour cells.. Read More»
  DOI: 10.4172/2169-0022.1000414

  Abstract PDF