Medicinal Chemistry

Dinesha Nanjegowda

Publications

• Research Article
  Cytoprotective Properties of Antioxidant Protein from Curry leaves (Murraya koenigii L.) against Oxidative Stress Induced Damage in Human Erythrocytes
  Author(s): Mylarappa B Ningappa, Dinesha Ramadas, Dinesha Nanjegowda, Kiruthika Balasubramanian, Khusdeep Chahal, Sachin Patil and Leela SrinivasMylarappa B Ningappa, Dinesha Ramadas, Dinesha Nanjegowda, Kiruthika Balasubramanian, Khusdeep Chahal, Sachin Patil and Leela Srinivas
  
  Oxidative stress induced by reactive oxygen species (ROS) cause lipid peroxidation at the human erythrocyte membrane with subsequent alterations in the ATPases function. In this study, potential cytoprotective activities of previously reported ”Antioxidant Protein from Curry leaves (APC)’’ in erythrocytes against reactive oxygen (ROS) species generated by pro-oxidants in vitro. The APC prevented red blood cell lysis induced by pro-oxidants; Fe: As (2:20 μmole), Hydrogen peroxide (0.2 mM), and tertiary butyl hydroperoxide (1 mM) upto 97.5, 82.5 and 63%, respectively. Further, APC prevented Fe:As induced K+ leakage in red blood cells up to 95%. The inhibition offered by APC on K+ leakage was comparable to inhibition offered by quinine sulphate, a known K+ channel blocker. Interestingly, the APC at dose dependently restored Na+K+ ATP.. Read More»
  DOI: 10.4172/2161-0444.1000328

  Abstract PDF