Molecular and Genetic Medicine

Dissanayake VHW

Publications

• Mini Review
  Development of Cytogenetic Abnormalities in Myelodysplastic Syndromes
  Author(s): Bandara WMMS, Rathnayake AJIS, Goonasekera HWW and Dissanayake VHWBandara WMMS, Rathnayake AJIS, Goonasekera HWW and Dissanayake VHW
  
  Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis resulting in cellular dysplasia and peripheral cytopenias. Research into MDS have found that both hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) in the nurturing niche of HSCs are genetically altered in MDS. In this review we present the existing views on the origin of cytogenetic abnormalities in HSC and MSC compartments in MDS. Based on the available data, we speculate that the origin of the chromosomal aberrations of the hematopoietic compartment occurs at the hematopoietic stem/ progenitor level. The genetic aberrations in MSC compartment appears to initiate independently from their hematopoietic counterparts. Whether the genetic events in both HSC and MSC compartments which lead to MDS occur simultaneously or at differ.. Read More»
  

  Abstract PDF