Journal of Cytology & Histology

D.M. Lang

Publications

• Research Article
  Antibody Markers for Studying Neurodegeneration in the Nothobranchius Central Nervous System
  Author(s): T. Genade and D.M. LangT. Genade and D.M. Lang
  
  Fish of the genus Nothobranchius have a naturally short lifespan in which they develop several neurological biomarkers of aging. This short lifespan (several months compared to several years in mice and zebrafish) make these fish a promising alternative in aging research. Resveratrol dosing retarded the development of the neurological biomarkers of aging identified in N. furzeri. Resveratrol's method of action was not determined due to the lack of celltype specific markers of degenerative processes. Further research of the Nothobranchius CNS and its degeneration is hampered by the lack of cell-type specific antibodies and other cellular markers of degenerative processes. In this article the authors present a molecular toolbox of five antibodies and a lectin which can be used to study the Nothobranchius central nervous system and its degeneration. These antibodies were tested against.. Read More»
  DOI: 10.4172/2157-7099.1000120

  Abstract PDF