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Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

D.O. Shapochka

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine,
Kyiv
Ukraine

Publications
  • Research Article
    Expression of Molecular Markers in Tumours of Patients with Breast Cancer
    Author(s): D.O. Shapochka, S P Zaletok and M I GnidyukD.O. Shapochka, S P Zaletok and M I Gnidyuk

    The expression of transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67, p53, Bcl-2 and E-cadherin in tumor tissue of 132 patients with breast cancer was investigated by immunohistochemistry. As a result of researches the correlation between Grade and expression of ER, PR, Bcl-2, Ki-67 and p65-subunit of NF-κB was defined. The level of proliferation was correlated with ER, PR, Bcl-2, p53 and Her2/neu expression. Also the correlation between some of investigated markers was found. Thus, high level of NF-κB nuclear expression was associated with Her2/neu hyperexpression and negative status of ER, PR and Bcl-2. These data may indicate poor prognosis and resistance to chemotherapy in breast cancer patients with activated NF-κB, but it requires further research and retrospective analysis of large number of patients... Read More»
    DOI: 10.4172/2157-7099.1000184

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Citations: 2476

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