Cancer Science & Therapy

Doaa M.Elghanam

Publications

• Research Article
  Prognostic Relevance of Ww-Oxidoreductase Gene Expression in Patients with Acute Lymphoblastic Leukemia
  Author(s): Walaa Fikry Elbossaty, Camellia Malak and Doaa M.ElghanamWalaa Fikry Elbossaty, Camellia Malak and Doaa M.Elghanam
  
  Background: The WWOX gene (WW-Oxidoreductase) gene is frequently lower expressed in variety of tumor. Methods: Screening for WWOX gene expression was assessed using real-time reverse transcriptase polymerase chain in 50 ALL cases and 50 healthy control. Results: WWOX gene was significantly lower in ALL cases (0.43239 ± 1.38925) when compared with healthy control (10.501 ± 9.0338) (p=<0.001). No significant differences were found between high and low WWOX gene expression regarding clinical data, age, sex, hematological data. Patients who highly expressed WWOX gene achieved CR at significantly higher rates in ALL (p=0.002), and had significantly lower frequency refractory disease in ALL patients (p=0.017). Higher expression WWOX gene patients have statistically longer OS (p=0.049) when compared with low expr.. Read More»
  DOI: 10.4172/1948-5956.1000367

  Abstract PDF