Journal of Tissue Science and Engineering

Dongsheng Xu

Publications

• Research Article
  RADA16-I Hydrogel-Released CXCL12 Stably Promotes Stem Cell Migration
  Author(s): Dandan Cheng, Janie Xu, Chengcheng Sun, Yanfei Li, Jian Fan, Jin Zhu, Dan Liu, Jing Zhao and Dongsheng XuDandan Cheng, Janie Xu, Chengcheng Sun, Yanfei Li, Jian Fan, Jin Zhu, Dan Liu, Jing Zhao and Dongsheng Xu
  
  Introduction: CXCL12 (Stromal cell-derived factor 1α, SDF - 1α) plays an important role in the nervous system development and neural repair, and is gradiently expressed in the central nervous system, mediating proper neural progenitor cell (NPCs) migration and survival. Due to a relatively short half-life and restriction of the blood-brain barrier (BBB) in systemic bioactive factor delivery, the delivery of CXCL12 and other bioactive factors has become a great challenge in research and clinical application. Aims: In order to observe the change of concentration grade and release time of CXCL12we studied the dynamic CXCL12 prolonged release pattern with the injectable, nontoxic, modifiable and degradable RADA16-I peptide hydrogel. The hydrogel resulted in a relatively stable CXCL12 concentration and provided more suitable microenvironm.. Read More»
  

  Abstract PDF