Medicinal Chemistry

Dongyan Gao

Publications

• Research Article
  Gallic Acid Attenuates Dimethylnitrosamine-induced Acute Liver Injury in Mice through Nrf2-mediated Induction of Heme Oxygenase-1 and Glutathione-s-transferase Alpha 3
  Author(s): Shaohua Ma, Li Lv, Qian Lu, Yubing Li, Feng Zhang, Musen Lin, Dongyan Gao, Kexin Liu, Xiaofeng Tian and Jihong YaoShaohua Ma, Li Lv, Qian Lu, Yubing Li, Feng Zhang, Musen Lin, Dongyan Gao, Kexin Liu, Xiaofeng Tian and Jihong Yao
  
  Gallic acid, a widely distributed phenolic acid present in various plant species, has been demonstrated to possess anti-inflammatory, antioxidant and anticarcinogenic properties. In this study, the protective effect of gallic acid on acute liver injury induced by dimethylnitrosamine in mice was investigated. We attempted to explore the molecular mechanism from a perspective of phase âÃ?â?¦¡ enzymes, which plays a crucial role in cellular defense against oxidative stress. Toxicant caused severe hepatic pathological damage and significant increase of serum transaminase levels. Hepatic lipid peroxidation and the glutathione depletion could also be observed after dimethylnitrosamine administration. Pretreatment of gallic acid at different doses could inhibit hepatic submassive necrosis and attenuate all the marker parameters i.. Read More»
  DOI: 10.4172/2161-0444.1000208

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