Journal of Environmental Analytical Chemistry

Dror Avisar

Publications

• Research Article
  Identification, Mechanisms and Kinetics of Macrolide Degradation Product Formation under Controlled Environmental Conditions
  Author(s): Igal Gozlan, Ilana Koren and Dror AvisarIgal Gozlan, Ilana Koren and Dror Avisar
  
  Erythromycin, azithromycin, clarithromycin and roxithromycin are antibiotics belonging to the widely used macrolide group. Their presence in the environment has been much investigated, despite the rapid degradation of Erythromycin to its spiroketal degradation product. In this study, the formation of macrolide degradation products was investigated in various aqueous solutions, each containing 100 μg/mL of the respective macrolide, under controlled artificial conditions: three phosphate buffer solutions (pH 5, pH 7 and pH 8.5), and a buffer solution at pH 7 with the addition of humic acids. Two solutions from natural sources were also examined: secondary effluent and tap water. The obtained degradation products were identified by their HRMS and NMR spectra (for Erythromycin-spiroketal, obtained from pure compounds isolated by preparative HPLC) as: N-oxide, N-desmethyl and N-didesmet.. Read More»
  DOI: 10.4172/2380-2391.1000171

  Abstract PDF