Journal of Tissue Science and Engineering

E. Cunningham

Publications

• Research Article
  Comparative Characterisation of 3-D Hydroxyapatite Scaffolds Developed Via Replication of Synthetic Polymer Foams and Natural Marine Sponges
  Author(s): E. Cunningham, N. Dunne, S. Clarke, Seong Ying Choi, G. Walker, R. Wilcox, R. E. Unger, F. Buchanan and C.J. KirkpatrickE. Cunningham, N. Dunne, S. Clarke, Seong Ying Choi, G. Walker, R. Wilcox, R. E. Unger, F. Buchanan and C.J. Kirkpatrick
  
  The production of complex inorganic forms, based on naturally occurring scaffolds offers an exciting avenue for the construction of a new generation of ceramic-based bone substitute scaffolds. The following study reports an investigation into the architecture (porosity, pore size distribution, pore interconnectivity and permeability), mechanical properties and cytotoxic response of hydroxyapatite bone substitutes produced using synthetic polymer foam and natural marine sponge performs. Infiltration of polyurethane foam (60 pores/in2) using a high solid content (80wt %), low viscosity (0.126Pas) hydroxyapatite slurry yielded 84-91% porous replica scaffolds with pore sizes ranging from 50?m - 1000?m (average pore size 577?m), 99.99% pore interconnectivity and a permeability value of 46.4 x10-10m2. Infiltration of the natural marine sponge, Spongia agaricina , yielded scaffolds with 56- .. Read More»
  DOI: 10.4172/2157-7552.S1-001

  Abstract PDF