Pulmonary & Respiratory Medicine

Edgar M Williams

Publications

• Research Article
  Assessing Perceptual Sensitivity of Respiratory Load Using Constant Airway Resistance
  Author(s): Tom Powell and Edgar M WilliamsTom Powell and Edgar M Williams
  
  Introduction: Breathlessness or dyspnoea is a complex subjective sensation that is an important feature of cardio-respiratory disease which is difficult to quantify. An objective measure would be useful as it would allow patients symptoms and response to therapy to be summarized and compared. Objectives: This study aims to investigate whether a new approach could be used to quantify resistive load detection in participants with healthy lungs or obstructive lung disease with breathlessness. Methods: Sixteen participants (five with chest disease, MRC dyspnoea score 4) were variously tested using three respiratory loading protocols, and applying a resistance between 0.2 to 1.5 kPa.L.sec-1 . Results: In a healthy group (n=11) a sigmoidal relationship between load detection and applied load was observed with the 50% detection rate being 0.5 kPa.L.sec-1 and a minimal.. Read More»
  DOI: 10.4172/2161-105X.1000236

  Abstract PDF