Nuclear Medicine & Radiation Therapy

Edward A. Monaco III

Publications

• Research Article
  Leukoencephalopathy after Whole Brain Radiation Therapy Plus Radiosurgery Versus Radiosurgery Alone for Metastatic Melanoma to the Brain
  Author(s): Phillip A. Choi, Ajay Niranjan, Hideyuki Kano, L. Dade Lunsford and Edward A. Monaco IIIPhillip A. Choi, Ajay Niranjan, Hideyuki Kano, L. Dade Lunsford and Edward A. Monaco III
  
  Advances in the treatment of melanoma with novel systemic therapies have meaningfully increased survival of patients. The brain is a common early site for melanoma metastases. WBRT is of limited effectiveness for radioresistant histologies such as melanoma and has been associated with white matter change and cognitive dysfunction. Prior studies of leukoencephalopathy after treatment with whole-brain radiation therapy (WBRT) and/or stereotactic radiosurgery (SRS) have focused on pathologies where chemotherapy is reflexively used in the majority of patients. The study’s aim was to evaluate the risk of leukoencephalopathy in patients with melanoma brain metastases receiving stereotactic radiosurgery and whole-brain radiation therapy versus SRS alone. We retrospectively reviewed 63 patients who underwent SRS with or without WBT between April 1988 and December 2012. Degree of leukoen.. Read More»
  DOI: 10.4172/2155-9619.1000225

  Abstract PDF