Journal of Blood & Lymph

Eldin AMK

Publications

• Case Report
  Role of BIRC5 Gene as a Prognostic Marker in Pediatric Acute Lymphoblastic Leukemia
  Author(s): Al-Sharkawy E, Ghobrial AG, Eldin AMK, Saber MM, Aboul-Fotoh LE and El-Deen HTGAl-Sharkawy E, Ghobrial AG, Eldin AMK, Saber MM, Aboul-Fotoh LE and El-Deen HTG
  
  Background and objectives: Acute lymphoblastic leukaemia (ALL) is the most common malignancy diagnosed in children. Survivin, a small inhibitor-of-apoptosis protein (IAP) encoded by the baculoviral inhibitor of apoptosis repeat-Containing 5 (BIRC5) gene, plays critical roles in malignancy by preventing apoptosis through blocking caspase activity. The aim of this study was to assess the prognostic role of BIRC5 gene in paediatric ALL.Subjects and methods: The present study was carried out on 42 children with the’ novo ALL who were followed up for two years and 10 apparently healthy children of matched age and sex (controls). Each child was subjected to complete history taking, clinical examination, laboratory investigations the form of CBC, Leishman-stained peripheral blood smears, Lactate dehydrogenase (LDH), Bone marrow (BM) aspiration an.. Read More»
  DOI: 10.4172/2165-7831.1000152

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