Journal of AIDS & Clinical Research

Elizabeth T Golub

Publications

• Research Article
  Development of IgG Mediated Antibody Dependent Cell-mediated Cytotoxicity (ADCC) in the Serum and Genital Mucosa of HIV Seroconverters
  Author(s): Mariam Aziz, Fareeha Mahmood, Mariana Mata, Helen G Durkin, Chenglong Liu, Ruth M Greenblatt, Marek Nowicki, Elizabeth T Golub, Kathryn Anastos, Audrey L French and Linda L BaumMariam Aziz, Fareeha Mahmood, Mariana Mata, Helen G Durkin, Chenglong Liu, Ruth M Greenblatt, Marek Nowicki, Elizabeth T Golub, Kathryn Anastos, Audrey L French and Linda L Baum
  
  Background: We measured antibody-dependent cell mediated cytotoxicity (ADCC) activity in serum and genital fluids of heterosexually exposed women during HIV seroconversion. Methods: Plasma and cervico-vaginal lavage (CVL) fluid from 11 seroconverters (SC) were analyzed biannually from one year pre- to 6 year post-seroconversion using a 51Cr-release assay to measure HIV-1 gp120 specific ADCC. Results: No SC had significant HIV specific CVL ADCC activity before seroconversion or until 1.5 yr after seroconversion. One individual had a %Specific Release (SR) of 25.4 at 2 years, 26.7 at 3 years and 21.0 at 4 years after seroconversion in CVL. Another sample had 4.7% SR at 2 years, 5.3 at 3 years, 10.9 at 4 years, and 8.4 at 5 years after seroconversion in CVL. A third had no activity until 17% SR 5 years after seroconversion in CVL. A fourth showed acti.. Read More»
  DOI: 10.4172/2155-6113.1000479

  Abstract PDF