Malaria Control & Elimination

Elsie O. Adewoye

Publications

• Research Article
  A One-compartment Constant Rate Intravascular Infusion Model for the Evaluation of Increases in Hematocrit after Artemisinin-based Combination Treatments of Acute Falciparum Malaria in Children
  Author(s): Akintunde Sowunmi, Kazeem Akano, Adejumoke I. Ayede, Godwin Ntadom, Temitope Aderoyeje, Elsie O. Adewoye and Bayo FatunmbiAkintunde Sowunmi, Kazeem Akano, Adejumoke I. Ayede, Godwin Ntadom, Temitope Aderoyeje, Elsie O. Adewoye and Bayo Fatunmbi
  
  Increases in hematocrit frequently follow successful treatment of uncomplicated falciparum infections in children, but there is no pharmacokinetic model for the analyses of the increases in hematocrit following artemisinin-based combination treatments (ACTs) in malarious children. A one-compartment constant rate intravascular infusion model (CRIVIM), which employed the principles of constant rate intravenous infusion of drugs (CRIVID), was used to evaluate the kinetics of the increases in hematocrit after artesunate-amodiaquine (AA) or artemether-lumefantrine (AL) treatments in 112 malarious children. The model assumed baseline hematocrit was zero, a constant rate increase in hematocrit from baseline following treatment, and it involved semi-logarithm plots of the difference between hematocrit at plateau and that at earlier times, against the corresponding times. Hematocrit reached a .. Read More»
  

  Abstract PDF