Molecular and Genetic Medicine

Eng-Zhuan B

Publications

• Research Article
  Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC
  Author(s): Eng-Zhuan B, Munn-Sann L, Chong PP, Yoke-Yeow Y, Siew-Ying CL and Rahman HAEng-Zhuan B, Munn-Sann L, Chong PP, Yoke-Yeow Y, Siew-Ying CL and Rahman HA
  
  Background: Nasopharyngeal carcinoma (NPC) is a rare form of cancer. NPC is the 4th most common cancer in Malaysia and the incidence rate for Malaysian Chinese is exceptionally high compared to other races. NPC is considered as a relatively radiosensitive tumor and patients diagnosed at early stages tend to survive longer compared to those who with advanced disease. Given that early symptoms of NPC are non-specific, and that the nasopharynx is relatively inaccessible, less invasive screening methods such as biomarker screening might be the key to improve NPC survival and management. Methodology: A matched case-control study was conducted to investigate the effect of hOGG1 Ser326Cys, ITGA2 C807T and TNF-α -308G>A polymorphisms on the risk of nasopharyngeal carcinoma and all-cause survival. hOGG1 gene encodes for a DNA glycosylase, a protein that is involved in DNA repair. ITGA2.. Read More»
  DOI: 10.4172/1747-0862.1000314

  Abstract PDF