Journal of Spine

Erhan Arslan

Publications

• Research Article
  Effects of Rifampicin on Experimental Spinal Cord Ischemia/Reperfusion Injury in Rats
  Author(s): Erhan Arslan, Ertugrul Cakir and Murat Selcuk EminagaogluErhan Arslan, Ertugrul Cakir and Murat Selcuk Eminagaoglu
  
  Objective: The effect of rifampisin was examined using a spinal cord ischemia/reperfusion (I/R) injury model in rats. Materials and Methods: 25 Wistar Albino rats weighing 200-250 g were used for the study. Rats were divided in 5 groups. After laparatomy, aorta was clamped 45 minutes below the left renal artery in all groups except shamoperated group. 1 cc saline was injected to vehicle group and rifampicin (20 mg/kg) was administered to treatment group intraperitoneally. In group 5, 20 mg/kg of rifampicin applied intraperitoneally before laparotomy. 2 hours after application of rifampicin, the animals underwent clip compression for 45 minutes after exposure of the abdominal aorta. At 1 h and 24 h, all groups were examined for neurologic outcome according to Tarlov scale. At 24 h, rats were sacrificed. The spinal cord was excised by laminect.. Read More»
  DOI: 10.4172/2165-7939.1000167

  Abstract PDF