International Journal of Neurorehabilitation

Ersilia Romanelli

Publications

• Research Article
  Incobotulinumtoxina (Xeomin®) Versus Onabotulinumtoxina (Botox®): Evaluation of Clinical Onset of Action with Rating Scales and Electroneurography
  Author(s): Lucia Mastromauro, Paolo Trerotoli, Ersilia Romanelli, Riccardo Giuseppe Marvulli and Giancarlo IanieriLucia Mastromauro, Paolo Trerotoli, Ersilia Romanelli, Riccardo Giuseppe Marvulli and Giancarlo Ianieri
  
  Onset of action, duration and maximum efficacy of different botulinum toxin type A (BoNT/A) preparations have been compared mainly in in vitro studies. This single-center open study compared onset of action of the two BoNT/A preparations onabotulinumtoxinA (complex size 900 kDa) and incobotulinumtoxinA (free of complexing proteins, 150 kDa) in patients with spasticity after cerebral stroke over a 15-day treatment period. Outcome measures were changes in muscle tone, increase in passive extension of the elbow, changes in limb functionality, and variation of the amplitude of the compound muscle action potential (cMAP) determined by electroneurography. A total of 108 patients (mean age 64.8 ± 11.3 years) were included in the study, 54 in each treatment arm. Muscle tone, elbow motion range, and limb function significantly improved in both groups fr.. Read More»
  DOI: 10.4172/2376-0281.1000182

  Abstract PDF