Molecular Biomarkers & Diagnosis

Eugene Jansen

Publications

• Research Article
  Biomarkers of Selenium Toxicity after Sub-Acute Exposure in Mice
  Author(s): Eugene Jansen, Dale Viezeliene, Piet Beekhof, Eric Gremmer, Hiliaras Rodovicius, Ilona Sadauskiene and Leonid IvanovEugene Jansen, Dale Viezeliene, Piet Beekhof, Eric Gremmer, Hiliaras Rodovicius, Ilona Sadauskiene and Leonid Ivanov
  
  Selenium (Se) is a trace element, essential for human health but it can be toxic at moderately higher intake levels. In this study biomarkers of Se toxicity after sub-acute intra-peritoneal exposure to Se (62.5 µg Se/kg bw/ day; 14 days) were investigated in mice. Such exposure corresponds to high human Se-intake levels. Focus was put on the biomarkers of systemic effects and on the toxicity in liver, kidney and brain. The sub-acute exposure to Se resulted in an increase in the concentrations of systemic inflammation biomarkers IL-6 (p=0.025) and resistin (p=0.049) and in a decrease of TNF-α (p=0.008). No effect on concentrations of MCP-1, tPAI-1, leptin and insulin was observed in serum. Also biomarkers of oxidative stress, anti-oxidant parameters and enzymes ALT and AST were not affected. In the tissue homogenates of liver, kidney and brain changes were observed in the act.. Read More»
  DOI: 10.4172/2155-9929.1000150

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