Molecular Biology: Open Access

Eulàlia Genescà

Publications

• Review Article
  Implications of basic research in clinical practice: toward a personalized medicine in T-cell Acute Lymphoblastic Leukemia (T-ALL)
  Author(s): Guillem Berbis, Jordi Ribera, Josep Maria Ribera and Eulàlia GenescàGuillem Berbis, Jordi Ribera, Josep Maria Ribera and Eulàlia Genescà
  
  Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children and one of the main causes of death among childhood blood disorders. There are two subtypes according to the affected lymphoid progenitor: B-ALL and T-ALL. The T-ALL is the less common and historically was associated with poor prognosis in both adults and children, although at present, treatment outcomes do not differ significantly between the two types of ALL. The T-ALL subtype is the most complex and heterogeneous at the genetic level and currently the one with less new therapeutic alternatives available. This trend is changing thanks to the remarkable progress that is being made in understanding the biology involved. Advances in genomic research during last decade have largely contributed to this progress. Moreover many efforts are being made to identify which of this new basic data is relevant for clinical pr.. Read More»
  DOI: 10.4172/2168-9547.1000142

  Abstract PDF