Journal of Cytology & Histology

Fabio Rotondo

Publications

• Case Report
  Pituitary Ganglioneuroma: Case Report and Literature Review
  Author(s): Aydin Sav, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer, Humberto Uribe, Luis C Penagos, Eva Horvath and Kalman KovacsAydin Sav, Luis V Syro, Fabio Rotondo, Bernd W Scheithauer, Humberto Uribe, Luis C Penagos, Eva Horvath and Kalman Kovacs
  
  We present a case of pituitary ganglioneuroma occurring in a 25 year old woman who presented with headache and hemianopsia. The histologic, immunohistochemical, and ultrastructural features of this tumor support the view that these rare hypothalamic-pituitary tumors are independently functioning neurohormonal units. Immunostaining is strongly positive for neuron-specific enolase (NSE) in all tumor cells and cell processes and for synaptophysin in a few cells and fibers. Few cells closely associated with tumor cells are positive for S100 protein. The cell processes are positive for neurofilament antigen. Ultrastructural analysis documents a spectacular neoplasm of neural derivation. The tumor consists of ganglion cells and areas of neuropil. The most typical tumor cells have relatively lucent spherical nucleus with large nucleolus, and abundant cytoplasm harbors compact sacks of RER me.. Read More»
  DOI: 10.4172/2157-7099.1000203

  Abstract PDF