Molecular Biomarkers & Diagnosis

Fabrizio Signore

Publications

• Review Article
  Biomarkers for the Detection of Pre-Cancerous Stage of Cervical Dysplasia
  Author(s): Paz Elia, Stella Raizelman, Esti Katorza, Yosef Matana, Offer Zeiri, Zvi Boger, Manuela Cervelli, Paolo Mariotini, Cristina Vallone, Fabrizio Signore and Yehuda ZeiriPaz Elia, Stella Raizelman, Esti Katorza, Yosef Matana, Offer Zeiri, Zvi Boger, Manuela Cervelli, Paolo Mariotini, Cristina Vallone, Fabrizio Signore and Yehuda Zeiri
  
  Introduction: Early diagnosis of cancer can dramatically increase healing probability. However many cancer detection methods are time-consuming, invasive, and require skilled medical staff and/or expensive detection systems. Cervical cancer is the fourth most common malignant disease among women, and the fourth leading cause of cancer death in women worldwide. Aim: This pilot study sought to identify reliable biomarkers indicative of early stages of cervical dysplasia, by analysis of changes in volatile organic compound composition in urine samples. Methods: Urine samples of 17 patients with cervical intraepithelial neoplasia (CIN I) and of 9 healthy female subjects were used. The sample composition was analyzed using Gas-Chromatography-Mass-Spectrometry. The statistical analysis of the data was performed using sup.. Read More»
  DOI: 10.4172/2155-9929.1000255

  Abstract PDF