Journal of Cytology & Histology

Falode DT

Publications

• Research Article
  Immunohistochemical Characterization of Lymphocytic CD3/CD20 and Macrophage CD68 in the Germinal Epithelium of Pb and Se+Zn Treated Adult Sprague-Dawley Rats
  Author(s): Falana BA, Ogundele OM, Duru FI, Osinubi AA and Falode DTFalana BA, Ogundele OM, Duru FI, Osinubi AA and Falode DT
  
  Lead toxicity in the testes has been described to be capable of inducing cell death by apoptosis and necrosis. Such toxicity can be attenuated by selenium and zinc synergy treatment in trace amount. This study evaluates the role and distribution of macrophages/histocytes (CD68), B-Lymphocytes (CD20) and T-Lymphocytes (CD3) in the testes of lead, selenium and zinc treated rats. 60 F1 generation adult male Sprague-Dawley rats were divided into four groups of 15 animals each. Group 1 received normal saline, group 2: 100 mg/Kg of lead acetate, group 3: 100 mg/kg of lead acetate then 2.25 mg/ Kg each of Zinc (Chelated zinc) and Selenium (Sodium Selenium) and group 4: 2.25 mg/kg of zinc and selenium (Se+Zn). The duration of treatment was 56 days following which the animals were sacrificed on the 57th day and the testes harvested and fixed in Bouin’s fluid... Read More»
  DOI: 10.4172/2157-7099.1000171

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